Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women
نویسندگان
چکیده
OBJECTIVE To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes. RESULTS After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% CI 0.33-0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake. CONCLUSIONS Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.
منابع مشابه
Plasma 25-Hydroxyvitamin D and Progression to Diabetes in Patients at Risk for Diabetes
OBJECTIVE To investigate the association between vitamin D status, assessed by plasma 25-hydroxyvitamin D, and risk of incident diabetes. RESEARCH DESIGN AND METHODS Prospective observational study with a mean follow-up of 2.7 years in the Diabetes Prevention Program (DPP), a multicenter trial comparing different strategies for prevention of diabetes in patients with prediabetes. We assessed ...
متن کاملLow Serum Levels of 25-Hydroxyvitamin D in Association with Type 2 Diabetes in Indian Patients
Objective: Vitamin D deficiency is a common disorder worldwide and is indicated by low serum 25-hydroxyvitamin D levels. Recent studies have suggested an association of 25-hydroxyvitamin D deficiency with diabetes mellitus. The objective of this study is to investigate the relationship between 25-hydroxyvitamin D concentration and type 2 diabetes in South Indian patients. Materials and Methods...
متن کاملبررسی ارتباط سطح سرمی 25 هیدروکسی ویتامین - D با عوامل خطر ساز سندرم متابولیک در پزشکان شهر زنجان
Background and Objective: Previous studies indicate an inverse association of serum 25-hydroxyvitamin-D level with obesity, metabolic syndrome and cardiovascular events. This study was aimed to assess metabolic syndrome correlation with serum Vit-D levels of physicians in Zanjan city (Iran). Materials and Methods: In an analytical cross-sectional study, a total of 108 physicians were selected a...
متن کاملAssociation between plasma 25-hydroxyvitamin D levels and fracture risk: the EPIC-Oxford study.
The importance of vitamin D for bone health is well established, but few data exist on the relation between plasma levels of 25-hydroxyvitamin D and risk of fracture. The authors examined this association within the EPIC-Oxford (European Prospective Investigation into Cancer and Nutrition-Oxford cohort) study of men and women in the United Kingdom (1993-1999). Five years after recruitment, part...
متن کاملThe relationship between serum 25-hydroxy vitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects
Background: Vitamin D is one of the known lipoprotein hormones with metabolic properties. We aimed to determine the serum 25-hydroxy vitamin D concentration in overweight/obese subjects with diabetes mellitus type Ⅱ (DM Ⅱ) in association with systolic and diastolic blood pressure and quality of life compared with healthy participants. Methods: The current case-control study was carried out amo...
متن کامل